We all know they’ll suppress urge for food, decrease blood sugar, and result in dramatic weight reduction. We additionally know that they arrive with negative effects, which might embody nausea, diarrhea, and vomiting. However we’re nonetheless studying about a few of their different results.
On the one hand, these seemingly miraculous medicine seem to enhance well being in different methods, serving to to guard in opposition to coronary heart failure, kidney illness, and doubtlessly even substance-use problems, neurodegenerative illnesses, and most cancers.
However on the opposite, they look like dangerous to some individuals. Their use has been linked to critical circumstances, being pregnant problems, and even some deaths. This week let’s check out what weight-loss medicine can do.
Ozempic, Wegovy, and different comparable medicine are referred to as GLP-1 agonists; they mimic a chemical made within the gut, GLP-1, that will increase insulin and lowers blood ranges of glucose. Initially developed to deal with diabetes, they’re now identified to be phenomenal at suppressing urge for food. One key trial, printed in 2015, discovered that over the course of round a 12 months, individuals who took one explicit drug misplaced between round 4.7% and 6% of their physique weight, relying on the dose they took.
Newer variations of that drug had been proven to have even greater results. A 2021 trial of semaglutide—the lively ingredient in each Ozempic and Wegovy—discovered that individuals who took it for 68 weeks misplaced round 15% of their physique weight—equal to round 15 kilograms.
However there look like different advantages, too. In 2024, an infinite examine that included 17,604 individuals in 41 international locations discovered that semaglutide appeared to scale back coronary heart failure in individuals who had been chubby or overweight and had heart problems. That very same 12 months, the US authorised Wegovy to “scale back the chance of cardiovascular dying, coronary heart assault, and stroke in (chubby) adults with heart problems.” This 12 months, Ozempic was authorised to scale back the chance of kidney illness.
And it doesn’t finish there. The numerous customers of GLP-1 agonists have been reporting some sudden constructive negative effects. Not solely are they much less taken with meals, however they’re much less taken with alcohol, tobacco, opioids, and different addictive substances.
